Clinical Trials

Two dietary supplement clinical trials were conducted with healthy volunteers, investigating the co-administration of a highly refined, SOE-containing grapefruit extract with the HIV protease inhibitor saquinavir. The first trial involved 12 volunteers in a double blinded, placebo controlled study with a randomized crossover period of two weeks, using a liquid formulation of the SOEs. The second study involved 4 volunteers comparing liquid SOE to capsule SOE to placebo. An average 40-fold increase in the blood levels of saquinavir was observed.


Pharmacokinetic Curves


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